Claudio Barrientos

Research

How does AI actually become enterprise value?

A research program exploring why organizations with access to similar AI technologies produce radically different economic outcomes.

This page is the home of the research program: its central question, the three streams it is organized in, the frameworks each stream develops, and the publications and articles that document it. It evolves as the work does.

The causal chain at the center of the program

AIIntelligenceDecisionsActionsOperational outcomesValueReinvestmentCapabilitiesMore valuethe cycle compounds

One research agenda, seven connected frameworks

AI Leadership Debtwho can govern AIArchitecture & Governance Debtwhat accumulates unseenEvolution-Ready PoChow pilots are builtAI Operating Modelhow they scaleAI Value Realization (AVRT)how value is convertedMeasurement Systemhow it is made visibleAI Capital Allocationhow it is reinvestedEach framework addresses one point where the conversion chain breaks

Each framework addresses one point where the conversion chain breaks: the leadership that cannot yet govern AI, the architecture and governance debt that accumulates, the way pilots are built, the operating model that scales them, the measurement that makes value visible, and the capital allocation that reinvests it.

01Three research streams

AI Value Realization

Why do similar AI capabilities produce such different returns?

Organizational and economic research on how AI investment converts into decisions, actions and measurable value. Includes AVRT and its measurement system, the debt concepts (leadership, architecture, governance) and capital allocation across AI portfolios.

Frameworks in this stream

  • AI Value Realization Theory (AVRT)
  • AI Leadership Debt
  • Architecture Leadership Debt
  • Governance Debt
  • AVRT Measurement System
  • AI Capital Allocation

Publications & evidence

  • AVRT working paper v3 (in progress; executive brief published on LinkedIn, Aug 2026)
  • AVRT Series, Parts 1–3, and the AI Strategic Portfolio series (LinkedIn, 2026)

02Three research streams

Industrial AI

How do machine learning and agents change the control of complex physical processes?

Applied research at the frontier of process control and AI: ML-driven adaptive control (MPC/APC) for non-linear mining processes, digital twins and operator training simulators, computer vision at scale, and operational AI agents integrating thousands of real-time signals.

Frameworks in this stream

  • Evolution-Ready PoC
  • Expert Validation Loop
  • Agent Harness Engineering

Publications & evidence

  • Barrientos C., Neira N., Olivares J., et al. “Non-linear Adaptive APC: ML-Driven Optimization for Copper Mining.” APC Peru, 2025.
  • Barrientos C., et al. “Adaptive APC Strategy using ML for SAG Grinding.” APC Peru, 2024.
  • Earlier work: geometallurgical predictive models and AutoML in Chilean mining (CORFO / PIA-CONICYT); Hydrometallurgy (Elsevier).

03Three research streams

Healthcare AI

Can machine learning support treatment decisions for older adults with cancer?

Clinical decision support in oncology and geriatric oncology: multivariable ML models for chemotherapy eligibility and treatment intensity, external validation across hospitals, and agentic clinical platforms. Developed through Oncoger.ai and the CORFO-funded PRECISION-IA program.

Frameworks in this stream

  • Expert Validation Loop

Publications & evidence

  • Navarrete G., Martínez G., Barrientos C., et al. “ML-Based Systemic Therapy Decision Support in Older Adults with Cancer.” Journal of Geriatric Oncology, 2026.
  • Models with ~0.90 ROC AUC in external-cohort validation; platform deployed in 10+ hospitals in Latin America.

Publications

Publications

Peer-reviewed research

  • Navarrete G., Martínez G., Barrientos C., et al. “ML-Based Systemic Therapy Decision Support in Older Adults with Cancer.” Journal of Geriatric Oncology, 2026.
  • 10+ peer-reviewed publications in Hydrometallurgy (Elsevier), SPIE Astronomical Instrumentation and Space Terahertz Technology, 2005–2016.

Industry research

  • Barrientos C., Neira N., Olivares J., et al. “Non-linear Adaptive APC: ML-Driven Optimization for Copper Mining.” APC Peru, 2025.
  • Barrientos C., et al. “Adaptive APC Strategy using ML for SAG Grinding.” APC Peru, 2024.

Working papers

  • Barrientos C. “AI Value Realization Theory (AVRT): a conversion model of AI value in organizations.” Working paper v3, 2026. Available on request.

Thought leadership

  • Articles, series and carousels published on LinkedIn and reproduced in the Insights section, grouped by topic.

05Currently exploring

Open questions on the research agenda

Four questions currently shaping the work. Comments, counter-evidence and collaboration are welcome.

  1. 01

    Can AI value realization be measured as a conversion system?

    AVRT Measurement System

  2. 02

    Can AI Leadership Debt explain persistent differences in AI ROI between organizations?

    AI Leadership Debt

  3. 03

    How should organizations allocate capital across AI initiatives under organizational uncertainty?

    AI Capital Allocation

  4. 04

    How should AI PoCs be architected to maximize learning without creating Architecture Leadership Debt?

    Evolution-Ready PoC · Architecture Leadership Debt